Reanalysis of molluscan metallothionein genes registered in NCBI
Jong Min Chung, Hee Ju Hwang, Min Kyu Sang, Hye Rin Min, Jie Eun Park, Hang Chul Cho, Se Won Kang, So Young Park, Wan Jong Kim, Ki Yoon Jung, Cheol Young Choi, Yeon Soo Han, Jun Sang Lee and Yong Seok Lee
Department of Life Science and Biotechnology, College of Natural Sciences, Soonchunhyang University, Asan, Chungnam, 31538, Republic of Korea Biological Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup, 56212, R
Metallothionin (MT) is well-known as a biomarker gene induced by various stimuli including heavy metals in vertebrates and invertebrates. This leads many researchers to conduct molecular phylogenetic analysis on the basis of the MT gene and amino acids in the world. In the mollusks, however, it is hard to identify the classification and types of MT even with the MT sequences registered in NCBI. In this study, the mollusks MT genes from NCBI were reanalyzed to establish the taxonomic importance of MT. To this end, 180 complete MT amino acid sequences out of the analyzed 247 mollusks MT sequences obtained from NCBI were selected. Through the association analysis, 58 MT genes were categorized as 12 groups based on molecular phylogenetic analysis. We also analyzed the status of Mollusks MT-related studies through pubmed search. Based on this study, we constructed a website to increase the utilization of the analyzed data by sharing the related information through the following website (http://bioinfo.sch.ac.kr/metallothionein). Thus, it will be much easier and faster to annotate and conduct molecular phylogenetic analysis with any MT gene derived from RNA-seq and Genome-seq data of new mollusks in the future.
  
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